International Journal of Pharmaceutical Science and Health Care Issue 4, Vol 2.March- April 2014 Available online on http://www.rspublication.com/ijphc/index.html ISSN 2249 – 5738

The present study was conducted aiming to evaluate the possible hematological and biochemical alterations induced by sub-chronic administration of Deltamethrin on liver, spleen, gastrocnemius muscle and small intestine of swiss albino male mice, Mus musculus. Animals under investigation were treated with two doses of deltamethrin, (3 mg/kg body weight and 6 mg/kg body weight) dissolved in peanut oil for a period of 45 days. Deltamethrin intoxication induced marked alterations in key hematological indices viz. WBC, Lymphocytes, Monocytes, Granulocytes, RBC, HGB, HCT, MCV, MCH, MCHC, PLT, MPV and PCT. Similar differences were observed in total protein and cholesterol content of control and test tissues. Activities of key enzymes like alkaline phosphatase (ALPase), acid phosphatase (ACPase), succinate dehydrogenase (SDH) and adenosine triphosphatase (ATPase) was also found to be affected in a dose dependent manner on the termination of experiment. Hence, it can be concluded that the application of these insecticides calls for strict monitoring as injudicious use may manifest many undesirable effects in non-target organisms. Further in-depth biochemical and histological studies are in progress to completely elucidate the toxic effect of this rampantly used pyrethroid.